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KMID : 0365819830230020469
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Journal of Pusan Medical College
1983 Volume.23 No. 2 p.469 ~ p.474
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Serum TSH and Prolactin Respnose to Intravenous Administration of Thyrotropin-releasing Hormone
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Abstract
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Synthetic thyrotropin releasing hormone, L-pyroglutamyl L-histidyl L-proline amide in dose of 4C0 μg has been administered intravenously to 30 cases of normal subject(female) and 40 cases of female patient with thyroid disease (20; hyperthyroidism, 20: primary hypothyroidism), diagnosed in the department of internal medicine, Pusan University Hospital during the period from March 1983 to Nov. 1983.
And its effects was assessed by serial measurement of serum thyrotropin and prolactin. The following results were obtained;
1. The mean basal serum TSH and prolactin levels in normal subjects were 1.90p,IU/ml and 7.21 ng/ml and increased to 16.8p.IU/ml and 63.02ng/ml respectively at 25 min. after TRH admini stration.
2. In patients with hyperthyroidism, the mean basal serum TSH and prolactin were 0.79pIU/ml and 5. 28ng/ml and increased to 1.28jIU/ml and 40.84ng/ml respectively at 25 min. after TRH adm-inisttration, which is significantly suppressed response compared to normal subjects (p<0.001).
3. In patients with primary hypothyroidism, the mean basal serum TSH and prolactin levels were 111.29jIU/ml and 8. 42ng/ml and increased to 358.53jIU/ml and 90.94ng/ml, which is signific-antly higher and more exaggerated response to TRH test compared to normal subjects (p<0.001).
4. The side effects of TRH administration, such as nausea, facial flushing, desire to urinate, which were mild and transient, were observed in 59 of 70 casess(84.3%).
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KEYWORD
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